The invention of the vitamins was a major scientific achievement in our understanding of well being and disease. In 1912, McDaid’s Casimir Funk initially coined the term «vitamine». The main period of discovery started in the early nineteenth century and ended at the mid-twentieth century. The puzzle of each vitamin was solved by way of the work and contributions of epidemiologists, physicians, physiologists, and chemists. Rather than a mythical story of crowning scientific breakthroughs, the truth was a sluggish, stepwise progress that included setbacks, contradictions, refutations, and a few chicanery. Analysis on the vitamins which can be related to major deficiency syndromes began when the germ concept of disease was dominant and dogma held that only four nutritional elements have been important: proteins, carbohydrates, fats, and minerals. Clinicians soon recognized scurvy, beriberi, rickets, pellagra, and xerophthalmia as specific vitamin deficiencies, slightly than diseases resulting from infections or toxins. Experimental physiology with animal models performed a basic role in nutrition research and enormously shortened the period of human affected by vitamin deficiencies. Finally it was the chemists who remoted the assorted vitamins, deduced their chemical structure, and developed strategies for synthesis of vitamins. Our understanding of the vitamins continues to evolve from the initial period of discovery.

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